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PVP VA64 as a novel release-modifier for sustained-release mini ...

The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) ( PVP VA64) as a novel release-modifier to tailor the drug release from ...

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(PDF) PVP VA64 as a novel release-modifier for sustained-release ...

12 Nov 2019 ... The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) ( PVP VA64) as a novel release-modifier to tailor the drug ...

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Solubility parameter-based screening methods for early-stage ...

10 Feb 2019 ... KEY FINDINGS: The rank order of itz miscibility with polymers using both conventional and novel δ-based approaches was 17PF > VA64 ...

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Taste masking of paracetamol by hot-melt extrusion: An in vitro and ...

Extruded granules containing high PMOL loadings in Eudragit EPO® (EPO) or Kollidon® VA64 (VA64) were prepared by hot-melt extrusion (HME). The taste ...

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Formulation and Optimization of Ezetimibe Containing Solid ...

6 Jan 2020 ... Solid dispersions were prepared by using Kollidon VA64 as carrier with different drug-to-carrier ratios. Dispersions with Kollidon VA64 were ...

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2019 AAPS PharmSci 360

5 Nov 2019 ... The supersaturation capacity of the SNEDDS (superSNEDDS) without and with Kollidon®VA64 were determined by sonicating and heating the ...

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Second VA-64 (U.S. Navy) - Wikipedia

VA-64 was an Attack Squadron of the U.S. Navy. It was established on 1 July 1961, and disestablished on 7 November 1969. The squadron was known as the  ...

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Dissolution enhancement of poorly water-soluble APIs processed by ...

16 Jan 2013 ... Soluplus and Crosslinked polyvinylpyrrolidone Kollidon VA64 were kindly donated by BASF (Ludwigshafen, Germany). Plasdone S630 was ...

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2019 AAPS PharmSci 360

5 Nov 2019 ... Purpose: Amorphous solid dispersions (ASD) are complex multicomponent ... In contrast, an impact on Mw and PDI of PVP-VA64 was detected ...

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Formulation and Optimization of Ezetimibe Containing Solid ...

with different drug-to-carrier ratios. Dispersions with Kollidon VA64 were prepared by melt extrusion technique. These formulations were characterized for solid ...

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Kollidon VA64, a Membrane-Resealing Agent, Reduces ...

16 Nov 2011 ... Loss of plasma membrane integrity is a feature of acute cellular injury/death in vitro and in vivo. Plasmalemma-resealing agents are protective ...

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JP5913207B2 - Drug delivery system comprising a solid solution of ...

The compositions of the present invention have weakly basic therapeutics with drug ... 190 g nifedipine and 380 g Kollidon VA64 were layered on 3154 g 25-30  ...

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Test of PHOBOS VA64-HDR1 chips

6 chips out of a batch of 94 chips were mounted on a MS3L hybrid (0006-string 0) . The chips were operated at our standard settings of. Vfp=-350mV. Vfs=+ ...

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Enhanced Dissolution Rate of Dronedarone Hydrochloride via ...

27 Aug 2019 ... Solid dispersion (SD) systems have been widely used to increase the ... using Vinylpyrrolidone‐Vinyl Acetate Copolymer (Kollidone® VA 64).

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Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH ...

4 Feb 2019 ... The dissolution behavior of the indomethacin:Kollidon VA64 extrudates was also studied as a function of the drug loading (from 5% to 90%).

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Phase behaviour analysis of solid dispersions of loperamide and ...

Dispersions with PVP-VA64, a less hydrophilic polymer, were investigated as well in order to study the influence of differences in polymer structure and water ...

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Formulation and Optimization of Ezetimibe Containing Solid ...

Solid dispersions were prepared by using Kollidon VA64 as carrier with different drug-to-carrier ratios. Dispersions with Kollidon VA64 were prepared by melt ...

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Enhanced Dissolution of a Porous Carrier-Containing Ternary ...

6 Oct 2019 ... copovidone (VA64), and polyvinyl alcohol-polyethylene glycol graft copolymer was evaluated to under- stand differences in dissolution rates ...

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Hot Melt Extrusion: Highlighting Physicochemical Factors to Be ...

11 Jul 2019 ... In addition to polymer and drug, other substances are necessary to ... VA64 were calculated, based on molecular structure and melting points, ...

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A wet-milling method for the preparation of cilnidipine ...

5 Nov 2019 ... using a wet-milling method with PVP VA64 as the steric stabilizer and SLS as the electrostatic ... In the present study, PVP VA64 and SLS were.

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The impact of reprocessing on typical physicochemical attributes ...

The purpose of this work was to evaluate the impact of successive reprocessing stages on typical physicochemical attributes of spray dried Kollidon® VA64, a ...

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Development of Solid Dispersion by Hot Melt Extrusion Using ...

SDs containing 5%-20% carvedilol, 0%-20% Acconon® C-50, and the remaining Kollidon® VA64 were prepared for hot melt extrusion. SDs were characterized ...

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Probing the Effect of Drug Loading and Humidity on the Mechanical ...

5 Nov 2012 ... Amorphous solid dispersions of clotrimazole in the polymer Kollidon VA64 were prepared as films in concentrations from 0% to 100% in 10% ...

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Evaluation of Different Polymers in 3D Printing Technologies ...

18 Oct 2019 ... The effects of additives such as plasticizing polymers/solubilizers on FDM 3DP have also been investigated. Kollidon® VA 64, Soluplus®, ...

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I ti ti Di t ib ti Investigation on Distributi g i th DSM X l P using the ...

Kollidon VA64, Soluplus (BASF) and Eudragit EPO were applied to all further. , p (. ) g. (E ik) d. d l b t investigations. (Evonik) were used as model substances.

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Solubility parameter based screening methods for early stage ...

Methods: Combinations of itz and Soluplus, Eudragit E PO (EPO), Kollidon 17PF (17PF) or Kollidon VA64 (VA64) were prepared as amorphous solid ...

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Kollidon® VA64 Fine

Recently, a new type of dry binder copovidone was developed: Kollidon® VA 64 Fine. Investigations on the application of Kollidon® VA 64 Fine in direct ...

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Figure 3 from The Pharmacokinetics and Pharmacodynamics of ...

Figure 3. (A) Pharmacokinetic data of Kollidon VA64 assessed during the first 24 hours after controlled cortical impact (CCI). At 1 hour after CCI, VA64 was given ...

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Influences of Different Drugs and Additives on the Glass Transition ...

It was found that the Tg value of Soluplus or Kollidon VA64 was decreased by adding all of the five substances. The Tg values of Soluplus with or without water  ...

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Rapid Assessment of Homogeneity and Stability of Amorphous Solid ...

15 May 2013 ... Amorphous solid dispersions were prepared with a Hot-Melt Extruder ... the NK1( Ant) combination with PVP VA64 was extruded at a higher ...

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Drug Delivery and Translational Research (v.8, #6) | www.chemweb ...

In this study, an inline UV/Vis spectrometer from ColVisTec was implemented in an ... QF/EC/PVP VA64 mini-matrices were extruded with 30% drug loading.

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Solubility enhancement technique for an anti-malarial drug using ...

The polymers like Kollidon VA-64 were used for solid dispersion using amino acids like Arginine was used. For preparation of solid dispersions, various solid.

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soluble APIs processed by hot-melt extrusion using hydrophilic ...

28 Mar 2012 ... Increased drug loadings of up to 40% were achieved in the extruded formulations for ... polyvinylpyrrolidone Kollidon VA64 were kindly.

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Determination of API Crystalline State in Hot Melt Extrudate ...

21 Apr 2019 ... These two tools were then employed to assess if the physical state of the API in the 13% and 20% Fenofibrate in Kollidon® VA64 polymer HME ...

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[Full text] Formulation and clinical investigation of optimized ...

28 Dec 2019 ... Results: A promising drug binary system with polyvinyl pyrrolidone vinyl acetate ( PVP-VA64) utilizing the lyophilization technique was ...

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Solubility and Dissolution Rate Enhancement of Curcumin Using ...

For solid dispersion preparation, Kollidon VA 64 polymer was selected ... Solid dispersion was prepared in a combination of Curcumin and Kollidon VA64 in a.

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Sridhar, Vishak - OhioLINK ETD

Urea was used as the dispersing agent for indomethacin, while Kollidon®VA64 was used for both indomethacin and phenytoin. Solid dispersions with urea and ...

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Development of ternary solid dispersions with hydrophilic polymer ...

In this study solid dispersions of carbamazepine in the hydrophilic Kollidon® VA64 polymer, adsorbed onto Neusilin® UFL2 adsorption carrier have been ...

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DISSOLUTION ENHANCEMENT OF POORLY WATER SOLUBLE ...

1 Jun 2019 ... Solid Solution was evaluated for saturation solubility, dissolution rate, XRD, ... Soluplus, kollidon VA64 and plasdone K29/32 were provided by ...

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Low temperature fused deposition modeling (FDM) 3D printing of ...

Two immediate release polymers, Kollidon VA64 and Kollidon 12PF were investigated as potential candidates for low-temperature FDM printing. Ramipril was ...

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